Primary open angle glaucoma (POAG) is a hereditary disease which can be tested with a DNA test. Glaucomas represent a group of diseases characterized by increased intraocular pressure, which causes retinal and optic disk destruction. Primary open angle glaucoma (POAG) in Beagles is an inherited condition with typically increased eye pressure in both eyes. Symptoms become detectable between 8 and 16 months of age. As the pressure in the eye increases, the eyeball increases in size and becomes painful. Symptoms include sudden onset of pain, redness, tearing, squinting and blinking of the eye. If POAG is left untreated, increased pressure in the eye leads to optic nerve damage and gradual loss of vision. Most dogs exhibit luxation of the lens by 2,5 years of age.
Inheritance: autosomal recessive - read more
Mutation: ADAMTS10 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.