Congenital ichthyosis (ICT)is a hereditary disease that can be tested with a DNA test. Congenital ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body. Different genodermatoses can occur in different dog breeds. In American Bulldog, dermatological signs include a generalized scaling (epidermal hyperplasia), dermal inflammation, erythema of the rostral muzzle with scaling and paw pad hyperkeratosis. Dermatological signs can be visible at as early as a few weeks of age.
Inheritance: autosomal recessive - read more
Mutation: NIPAL4 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.