Musladin-Lueke Syndrome (MLS)is a hereditary disease which can be tested with a DNA test. Musladin-Lueke Syndrome (MLS) is a hereditary disease in Beagle dogs that affects the development and structure of connective tissue and manifests with extensive fibrosis of the skin and joints. The syndrome is multi- systemic and is involved in defects of multiple organs and tissues, including bone, heart, skin, and muscle. Current evidence suggests that dogs that have two copies of the mutant gene are affected with MLS, making the sindrom a recesive. However the severity of clinical signs can be variable. Dogs inheriting only one copy of the mutant gene can show subtle signs but do not appear to have health-related defects.

Inheritance: autosomal recessive - read more

Mutation: ADAMTSL2 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.