Pituitary dwarfism is a hereditary disease which can be tested with a DNA test. Pituitary dwarfism is a metabolic disorder that affects German shepherds, Saarloos Wolfdogs and Czechoslovakian Wolfdogs. Pituitary dwarfism is characterized by a combined deficiency of growth hormone, thyroid-stimulating hormone (TSH), prolactin, and gonadotropins. The hormone deficiencies can lead to a wide range of clinical manifestations, but the most common ones are marked growth retardation, retention of lanugo or secondary hairs with concurrent lack of primary or guard hairs, and bilateral symmetrical alopecia. 

Inheritance: autosomal recessive - read more

Mutation: LHX3 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.