Progressive retinal atrophy (CNGA1-PRA) is a hereditary disease which can be tested with a DNA test. Progressive retinal atrophy (PRA) is a hereditary disease that occurs in many breeds of dogs and is reflected in various clinically indistinguishable forms. Progressive rod and cone degeneration in retina leads to progressive vision loss, which can end with total blindness. A form of PRA called CNGA1-PRA was described in Shetland sheepdog. On average clinical signs become apparent at 5 years of age (2-11 years). The breed suffers from an additional form of retinal degeneration (SPR), that progresses more slowly and does not cause such obvious visual impairment as does PRA. Unfortunately, there is no genetic test for SPR yet.
Inheritance: autosomal recessive - read more
Mutation: CNGA1 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.